Tracking microdeletions of the AZF region in a patrilineal line of infertile men
نویسندگان
چکیده
منابع مشابه
Tracking microdeletions of the AZF region in a patrilineal line of infertile men.
Male infertility is considered to be a difficult-to-treat condition because it is not a single entity, but rather reflects a variety of different pathologic conditions, thus making it difficult to use a single treatment strategy. Structural alterations in the Y chromosome have been the principal factor responsible for male infertility. We examined 26 family members of 13 patients with male infe...
متن کاملCytogenetic abnormalities and azoospermia factor (AZF) microdeletions in infertile men from Kuwait
Approximately 15% of couples in the reproductive age group worldwide are affected by infertility, and it is estimated that about 40-50% of infertilities are of male origin. Genetic factor accounts for 10-15% of severe male infertility, including chromosomal aberrations and single gene mutations (Ferlin et al, 2006). After the Klinfelter syndrome, Y chromosomal microdeletions are the most freque...
متن کاملAZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men.
AIM To evaluate for the first time the frequency of Y chromosome microdeletions and the occurrence of the partial deletions of AZFc region in Moroccan men, and to discuss the clinical significance of AZF deletions. METHODS We screened Y chromosome microdeletions and partial deletions of the AZFc region of a consecutive group of infertile men (n = 149) and controls (100 fertile men, 76 normosp...
متن کاملAZF deletions in infertile men from the Republic of Macedonia.
Y chromosome deletions in the three azoospermia factor (AZF) regions constitute the most common genetic cause of spermatogenic failure. The aim of this study was to estimate the length and boundaries of the AZF deletions and to correlate the AZF deletions with the sperm concentrations, testicular histology, Y haplogroups and the ethnic origin of the men with deletions. PCR analysis of STS loci ...
متن کاملThe prevalence of Y chromosome microdeletions in Pakistani infertile men
BACKGROUND Microdeletions of the azoospermia factor locus of the long arm of Y chromosome are an etiological factor of severe oligozoospermia or azoospermia. OBJECTIVE The aim of this study was to investigate the prevalence of Y-chromosome microdeletions in AZF region and their role in infertility in Pakistani population. MATERIALS AND METHODS The type of deletions in AZF locus were detecte...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2008
ISSN: 1676-5680
DOI: 10.4238/vol7-3gmr455